Out of the Inkwell was a major animated series of shorts during the silent era. It was produced by Max Fleischer from 1918-29 at Bray Studios, and latter by Inkwell Imps.
Fitz - Canine Companion
Koko the Clown -
Koko the Clown from Out of the Inkwell was brought into the world of Talkies when reintroduced as a Talkartoon by creator Max Fleischer. He would appear along side Betty Boop, and Bimbo.